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# tgcBIOMICS GmbH [EN]

The gene carrier company

## Beiträge

- [Partner](https://en.tgcbiomics.de/1577-partner/) - Animal Physiology and Immunology Food and Bioprocess Engineering
- [](https://en.tgcbiomics.de/1573-1573/)

## Seiten

- [Welcome to tgcBIOMICS!](https://en.tgcbiomics.de/) - tgcBIOMICS GmbH offers a broad range of services in the field of biotechnology. These include DNA isolation from different kind of sources and organisms, PCR amplification of target sequences as well as cloning into a broad range of plasmid vectors. Construction of synthetic genes could also be done in collaboration with third parties. When it
- [Product list as pdf-file](https://en.tgcbiomics.de/our-products/product-list-as-pdf-file/) - Here is the tgcBIOMICS product list 2026 as a PDF-file. If your specific antibody or antigen is not among those found on our product list, we will gladly work with you to custom-create your product. Please feel free to contact us.
- [ELISA kits](https://en.tgcbiomics.de/elisa-kits/) - ELISA kits Product Code Name and description Manual Format and Size Price in Euro (2026) TGC-E001-1 Simultaneous detection of C. difficile toxins A and B pdf-download 96well plate 405,00 TGC-E002-1 Separate detection of C. difficile toxins A and B pdf-download 96well plate 510,00 TGC-E099-1 Customized assembled C. difficile toxin A/B detection kit 96well plate On
- [Contact people](https://en.tgcbiomics.de/contact/contact-persons/) - Technology – Clostridium difficile – Patents Prof. Dr. von Eichel-Streiber, Chv.Eichel@tgcbiomics.de General information – Sales – Marketing – Export – Contracts – Financials support@tgcbiomics.de Others info@tgcbiomics.de
- [Imprint](https://en.tgcbiomics.de/imprint/) - tgcBIOMICS GmbH Franz-Kirsten-Str. 1, Gebäude 2 D-55411 Bingen Tel.: 06721-98419-0 Fax: 06721-98419-18 E-Mail: info@tgcbiomics.de Internet: tgcbiomics.de Business form: GmbH CEO and responsible for the content of this page: Prof. Dr. Christoph von Eichel-Streiber Commercial register: Amtsgericht Bad Kreuznach Company registration number: HRB 3890 Legal job title: TAX ID: DE 199 954 198 Rechtliche Hinweise
- [Downloads](https://en.tgcbiomics.de/informationen-zum-download/) - PDF collection Clostridium difficile in process to be updated Product list Our product list 2020 as a PDF-file Technology information Our company flyer with all important technology information will be updated. GTC General terms and conditions Company flyer in process to be updated
- [Toxins](https://en.tgcbiomics.de/toxins/) - The list of available Clostridium difficile toxins can be found in the table below. These toxins are always available in sufficient quantities. For larger quantities or toxins of ribotypes which are not listed here, please contact us for a specific offer. Clostridium difficile toxins Product Code (klick to view the specification sheet) Name Ribotype Amount
- [Publications](https://en.tgcbiomics.de/publications/) - Induction of antitoxin responses in Clostridium-difficile-infected patients compared to healthy blood donors. Clostridium difficile PCR Cycle Threshold Predicts Free Toxin. IgG Antibody Response to Toxins A and B in Patients with Clostridium difficile Infection Development and Optimization of a Novel Assay To Measure Neutralizing Antibodies against Clostridium difficile Toxins
- [Advisory board and management](https://en.tgcbiomics.de/about-tgcbiomics/advisory-board-and-management/) - Prof. Dr. med. Christoph von Eichel-Streiber is the founder of tgcBIOMICS and has been its director since 1999. His scientific work can be accessed in many databases. (www.ncbi.nlm.nih.gov/pubmed) Prof. Dr. med. Trinad Chakraborty is the founder of tgcBIOMICS. Dr. T. Chakraborty studied biology in London and Berlin and has been the director of medical microbiology
- [Proteins](https://en.tgcbiomics.de/proteins/) - Proteins Product Code Name Description Application Amount in µg TGC-P001-1 SipC rec. Purified recombinant SipC of Salmonella typhimurium produced in E. coli. Western Blot, ELISA 200 µg TGC-P101-1 EspA rec. Purified recombinant EspA of EHEC/EPEC produced in E. coli. Western Blot, ELISA 200 µg TGC-P102-1 EspB, rec Purified recombinant EspB of EHEC/EPEC produced in E.
- [Antibodies](https://en.tgcbiomics.de/antibodies/) - Antibodies directed against Clostridium difficile Product Code (click to view the specification sheet) Name Antigen/Species Produced in Species Application Amount in µg TGC-A001-1 TGC-2 Directed against Toxin A (TcdA) monoclonal, mouse Western Blot, ELISA 100 µg TGC-A003-1 TGC-54 Directed against Toxin A (TcdA) monoclonal, mouse Western Blot, ELISA 100 µg TGC-A004-1 TGC-101 Directed against Toxin
- [Approach](https://en.tgcbiomics.de/approach-2/) - Größere Kartenansicht
- [Clostridium difficile](https://en.tgcbiomics.de/clostridium-difficile/) - Clostridial Toxins in a new light Autocatalytic cleavage activates toxin B from Clostridium difficile (C. difficile) Diarrhea through to pseudomembranous colitis are often the complications associated with antibiotic therapy. The reason behind this is that the antibiotic brings the natural intestinal bacteria out of balance, therefore allowing damaging bacteria like C. difficile to take over.
- [tgcBIOMICS Technology](https://en.tgcbiomics.de/tgcbiomics-technology/) - Products Positioning Bacteria possess several advantages when applied in biotechnology: molecular biological methods were first established using bacteria, bacteria have a large capacity for foreign DNA, bacteria have a short replication time, bacteria could be efficiently eliminated (not possible when using viruses). The main
- [GDH](https://en.tgcbiomics.de/clostridium-difficile/portfolio/gdh/) - Detection of glutamate dehydrogenase (GDH) The detection of GDH is often the first step in the diagnosis of Clostridium difficile. Mainly used as a screening method, this assay could not differentiate between pathogenic and apathogenic strains. GDH detection kits are available and can be ordered from tgcBIOMICS. Please feel free to contact us.
- [<em>Clostridium difficile</em> strains](https://en.tgcbiomics.de/clostridium-difficile/portfolio/clostridium-difficile-strains/) - A wide variety of current clinical strains are readily available from tgcBIOMICS. These also include the known ribotypes and toxin types. Additionally, tgcBIOMICS samples collection consists of many atypical or non-toxin building rare strains which could be of great significance for the evaluation of diagnostic assays.
- [Diagnostic assays](https://en.tgcbiomics.de/clostridium-difficile/portfolio/assay-development/) - Especially for the pathogenic bacterium Clostridium difficile, tgcBIOMICS develops new applications for the rapid and sensitive diagnosis including a quick test for toxin A/B as well as ELISA assays f or the detection of toxin A/B or anti-Clostridium antibodies. An overview of the diagnostic assays developed by tgcBIOMICS and actually available you will find here.
- [Portfolio](https://en.tgcbiomics.de/clostridium-difficile/portfolio/) - tgcBIOMICS offers a broad range of scientific tools, for example highly purified Clostridium difficile toxins and antibodies directed against them and diagnostic assays. In addition, tgcBIOMICS offers services such as contract research, development, and production for both the pharmaceutical and diagnostic markets. Should you be interested in our products or services, please contact us.
- [Our expertise](https://en.tgcbiomics.de/clostridium-difficile/our-expertise/) - Under the direction of Dr. von Eichel-Streiber, after tgcBIOMICS was founded, the technological platform was further developed and research about C. difficile topics continued. Working as a specialized recipient laboratory for clinical and critical samples as well as in conjunction with the production of novel monoclonal antibodies in the European collaborative research project resulted in
- [<em>Clostridium difficile</em>](https://en.tgcbiomics.de/clostridium-difficile/clostridium-difficile/) - C. difficile is an anaerobic species of Gram-positive spore-forming bacteria that causes both diarrhea and complex intestinal illnesses. In many cases, gastrointestinal symptoms arise due to the deterioration of natural microbial flora of the intestine from an antibiotic therapy and simultaneous contact with C. difficile spores. Symptoms such as diarrhea, cramping/spasms, dehydration, fever, nausea and
- [PCR technology](https://en.tgcbiomics.de/clostridium-difficile/portfolio/pcr/) - Molecularbiology and Clostridium difficile For the detection of genetic markers of Clostridium difficile, tgcBIOMICS has established several PCR protocols of high sensitivity and specificity, for example: C. difficile ribotyping as suggested by the Robert-Koch-Institute detection of the binary toxin genes (cdtA/B) detection of the toxin genes tcdA and tcdB detection of a shortend variant of
- [Antibodies, toxins, proteins, and ELISA kits](https://en.tgcbiomics.de/our-products/antibodies-toxins-proteins-and-elisa-kits/)
- [List of tgcBIOMICS Patents](https://en.tgcbiomics.de/patentportfolio/list-of-tgcbiomics-patents/) - 1. WO9929884: „tgc Method for Inducing Targeted Somatic Transgenesis“ EP1023453 Patent pending: AU751517 Canada US6825028 Japan U.S.A. (divisional application) 2. WO2006108574: Method for the Delivery of Exogenous Antigens into the MHC Class I Pathway of Cells DE102005016234 Patent pending: U.S.A. Europe 3. WO2007016912: Test system for Detecting Salmonella Patent pending: Germany Europe U.S.A. 4. WO2007087851:
- [Our team](https://en.tgcbiomics.de/about-tgcbiomics/our-team/) - tgcBIOMICS staff is comprised of 8 motivated professionals, some of whom have been with our company since it was founded. Two bioscientists, a degreed engineer and a medical technical assistant among others are all part of our skilled laboratory team.
- [EU research projects](https://en.tgcbiomics.de/eu-research-projects/) - Contents are in the process of being updated.
- [Ribotyping](https://en.tgcbiomics.de/clostridium-difficile/portfolio/ribotyping/) - In many clinical cases, it is important to conduct an additional ribotyping by using step diagnostics once a positive finding of the Clostridium difficile infection has been determined. Depending on the ribotype, certain epidemiological and therapeutic measures can be deduced. tgcBIOMICS has developed new gene technology methods for diagnosing Clostridium difficile which assist in a
- [Sera](https://en.tgcbiomics.de/clostridium-difficile/portfolio/sera/) - Sera bank – samples During the past few years of research about Clostridium difficile, tgcBIOMICS was able to successfully collect the respective blood samples which correlated appropriately with the sample transmittals in many clinical cases. It is interesting to know that as in many other infectious illnesses a correlation between the infection and the immune
- [About tgcBIOMICS](https://en.tgcbiomics.de/about-tgcbiomics/) - Founded in 1999 by two internationally renown microbiologists, Dr. Christoph von Eichel-Streiber and Dr. Trinad Chakraborty, tgcBIOMICS (tgc=targeted genetic conditioning) focuses on the production of biotechnological components with molecular biological, immunological and microbiological background. Our company offers a wide range of biotechnological services and products. These include: DNA isolation from varying sources and organisms PCR
- [Services](https://en.tgcbiomics.de/contract-research-and-development/services/) - Cultivation of cell lines and bacteria DNA/RNA isolation from pro and eukaryotic cells/tissues as well as cloning and sequencing of target genes Recombinant production of antigens in – depending on the protein characteristics – various systems where prokaryotic or eukaryotic cells are used. Therefore, thanks to our modern digester, up to 30 liters of bacterial
- [Outsourcing](https://en.tgcbiomics.de/contract-research-and-development/outsourcing/) - During the past few years tgcBIOMICS has been an important contributing partner and has worked as an „extended workbench” in client driven experimental projects. Additionally, the outsourcing of work packages to be carried out under particular microbiological or molecular biological standards is becoming a more frequently used service within the life sciences realm. tgcBIOMICS can
- [Our products](https://en.tgcbiomics.de/our-products/) - The product portfolio of tgcBIOMICS is mainly comprised of native isolated and highly purified toxins (Clostridium difficile toxin A [TcdA] and B [TcdB]) out of various strains and ribotypes of the pathogenic bacterium Clostridium difficile as well as monoclonal and polyclonal antibodies directed against these proteins. In addition, tgcBIOMICS offers ELISA kits for the detection
- [Company profile](https://en.tgcbiomics.de/company-profile/) - tgcBIOMICS GmbH wurde 1999 von zwei international renommierten Mikrobiologen gegründet. Der Focus des Unternehmens liegt in der Nutzung von Bakterien zur Entwicklung und Produktion innovativer Bio-Pharmazeutika. BIOMICS ist die gezielte Steuerung biologischer Funktionen (targeted genetic conditioning) von Zellen, Geweben oder Organen durch Übertagung von DNA/RNA. targeted genetic conditioning macht Informationen aus der Analyse von Genen
- [Sitemap](https://en.tgcbiomics.de/sitemap/)
- [Contract research and development](https://en.tgcbiomics.de/contract-research-and-development/)
- [NEWS & Press](https://en.tgcbiomics.de/news-press/) - KEINE TEXTE & BILDER VORHANDEN
- [Job offers](https://en.tgcbiomics.de/job-offers/) - Soll dieser Punkt hier bleiben? Da wir ihn schon unter https://tgcbiomics.de/tgcbiomics-gmbh/offene-stellen/ haben.
- [ZIM](https://en.tgcbiomics.de/eu-research-projects/zim/)
- [Hyperdiff](https://en.tgcbiomics.de/eu-research-projects/hyperdiff/) - EU-Project Hyperdiff A european research project dealing with detection of hypervirulent strains of Clostridium difficile and the therapy of an infection with this important bacterium. Main focus is the inactivation of genes responsible for virulence as well as the development of new methods for the diagnosis of hypervirulent strains. More informations on: www.clostridia.net
- [Eurotransbio](https://en.tgcbiomics.de/eu-research-projects/eurotransbio/) - European stem cell research project (BIOSTECEL) started with tgcBIOMICS The biotech company tgcBIOMICS participates in the development of a new biosensor for detection of stem cells.
- [Toxins](https://en.tgcbiomics.de/clostridium-difficile/portfolio/toxins/) - An overview about the Clostridium difficile toxins actually available you will find here.
- [Antibodies](https://en.tgcbiomics.de/clostridium-difficile/portfolio/antibodies/) - A choice of antibodies against Clostridium difficile toxins A and B actually available you will find here.
- [tgc technology](https://en.tgcbiomics.de/tgcbiomics-technology/tgc-technology/) - in process.
- [tgc bacteria](https://en.tgcbiomics.de/tgcbiomics-technology/tgc-bacteria/) - in process.
- [Contact](https://en.tgcbiomics.de/contact/) - tgcBIOMICS GmbH Franz-Kirsten-Str. 1, Gebäude 2 D-55411 Bingen Tel.: 06721-98419-0 Fax: 06721-98419-18 E-Mail: info@tgcbiomics.de Internet: tgcbiomics.de
- [Bacterial expression system](https://en.tgcbiomics.de/tgcbiomics-technology/bacterial-expression-system/) - tgcBIOMICS has developed an innovative expression system using gram-positive bacteria (tgc bacteria) for the production of recombinant proteins. tgc bacteria posses several advantages as host for the production of recombinant proteins as well as for their use in research, diagnosis, and therapy. tgc bacteria are gram-positive no contamination of purified proteins with LPS tgc bacteria
- [News](https://en.tgcbiomics.de/news-press/news/)
- [Legal notice](https://en.tgcbiomics.de/imprint/legal-notice/) - 1. Haftungsbeschränkung Die Inhalte dieser Website werden mit größtmöglicher Sorgfalt erstellt. Der Anbieter übernimmt jedoch keine Gewähr für die Richtigkeit, Vollständigkeit und Aktualität der bereitgestellten Inhalte. Die Nutzung der Inhalte der Website erfolgt auf eigene Gefahr des Nutzers. Namentlich gekennzeichnete Beiträge geben die Meinung des jeweiligen Autors und nicht immer die Meinung des Anbieters wieder.
- [Patentportfolio](https://en.tgcbiomics.de/patentportfolio/) - KEINE TEXTE & BILDER VORHANDEN; hier könnten wir auch die Texte des Unterpunkts "Liste der tgcBIOMICS Patente" und diesen dafür Streichen.

## Kategorien

- [Allgemein](https://en.tgcbiomics.de/category/allgemein/)
- [Partners](https://en.tgcbiomics.de/category/partners/)